Preclinical Characterization andIn VivoEfficacy of GSK8853, a Small-Molecule Inhibitor of the Hepatitis C Virus NS4B Protein
نویسندگان
چکیده
منابع مشابه
A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry
Small molecule inhibitors of hepatitis C virus (HCV) are being developed to complement or replace treatments with pegylated interferons and ribavirin, which have poor response rates and significant side effects. Resistance to these inhibitors emerges rapidly in the clinic, suggesting that successful therapy will involve combination therapy with multiple inhibitors of different targets. The entr...
متن کاملA small-molecule inhibitor of hepatitis C virus infectivity.
One of the most challenging goals of hepatitis C virus (HCV) research is to develop well-tolerated regimens with high cure rates across a variety of patient populations. Such a regimen will likely require a combination of at least two distinct direct-acting antivirals (DAAs). Combining two or more DAAs with different resistance profiles increases the number of mutations required for viral break...
متن کاملTopology of the membrane-associated hepatitis C virus protein NS4B.
Hepatitis C virus (HCV) belongs to the Hepacivirus genus in the Flaviviridae family. Among the least known viral proteins in this family is the nonstructural protein NS4B, which has been suggested to be a part of the replication complex. Hydrophobicity plots indicate a common profile among the NS4B proteins from different members of the Flaviviridae family, suggesting a common function. In orde...
متن کاملPreclinical characterization of the inhaled small molecule respiratory syncytial virus L-protein polymerase inhibitor, PC786
250/250 words) 23 Although respiratory syncytial virus (RSV) is the most common cause of lower respiratory 24 tract infection in infants and young children, attempts to develop an effective therapy have so 25 far proved unsuccessful. Herein we report the preclinical profiles of PC786, a potent non26 nucleoside RSV L-protein polymerase inhibitor, designed for inhalation treatment of RSV 27 infec...
متن کاملPreclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor
Although respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in infants and young children, attempts to develop an effective therapy have so far proved unsuccessful. Here we report the preclinical profiles of PC786, a potent nonnucleoside RSV L protein polymerase inhibitor, designed for inhalation treatment of RSV infection. PC786 demonstrated a poten...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2015
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00813-15